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When combining Cardarine with LGD 4033 (Ligandrol) , it enhances your strength, helping you maintain muscle mass on your cuticles, and improves muscle tone and blood flow.

A study published on May 8, 2015 from the journal Frontiers in Human Neuroscience provides evidence for a potential role for cardarine in the treatment of Parkinson's disease. Results of the analysis were presented to the international meeting of the Society for Neuroscience in San Diego, California.

In the study, scientists evaluated the effects of low-dose (0.5 g/kg body weight) cardarine on rat behavior and brain functioning in order to establish a potential mechanism for cardarine's role as an effective treatment for Parkinson's disease.

In the study, rats received a single oral dose of 1 g/kg of cardarine over 8 weeks of daily administration. After treatment, the rats exhibited a rapid, sustained improvement in locomotor and behavioral activity and in the number of neurons in the substantia nigra. It is important to note that the effects of cardarine did not require a significant increase in the rats' doses of dopamine, the predominant neurotransmitter in these organs.

Cardarine was used in the brain regions where dopamine plays a role in locomotor activity, and its mechanism of action on dopaminergic mechanisms is well documented. Cardarine does not appear to alter dopamine concentrations in these brain regions in rats.

"This study provides the first evidence that when combined with low-dose cardarine in this setting, there may be a synergistic effect on the behavior of rat rats," says lead author Dr. John K. Hultgren, from Lund University, Sweden.

Cardarine also had beneficial effects for rats not treated with the drug. As expected, it increased levels of brain-derived neurotrophic factor in the substantia nigra and substantia granulosa, which are brain regions related to dopamine and related to Parkinson's disease. Cardarine also increased the number of neurons in these regions in a concentration-dependent manner.

"As expected, we found no beneficial effects on brain function in untreated rats," says Soren S. Hansen, from the Department of Pathology, Department of Physiology and Pharmacology, University of Lund, Sweden. "These effects observed with low doses of cardarine indicate that it has a therapeutic capacity in these tissues that does not depend on high doses."

To conduct this new study, researchers evaluated the dopamine, GABA, serotonin and cholinergic systems in two different groups of rats — one of which received a 5-HT3R antagonist, the other a 5-HT2R receptor antagonist.

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